Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Die traditionsreiche Reihe QUELLEN UND FORSCHUNGEN ZUR LITERATUR- UND KULTURGESCHICHTE gehört zum festen Bestand renommierter Publikationsforen der Deutschen Literaturwissenschaft. Von Mark-Georg Dehrmann und Christiane Witthöft herausgegeben, präsentiert die Reihe hochwertige wissenschaftliche Arbeiten, die literarische Texte im Zusammenhang mit kulturhistorischen Phänomenen untersuchen.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Accompanied by an introductory monograph and a full critical apparatus, this English-language edition of Karel van Mander’s _Grondt der edel, vry schilderconst_ (Foundation of the Noble, Free Art of Painting) provides unprecedented access to this crucially important art treatise on _schilderconst_ (the art of painting / picturing).

Patočka, J. Erinnerungen an Husserl.--Landgrebe, L. Philosophische Anthropologie - eine empirische Wissenschaft?--Schmidt, G. Was ist der Mensch?--Polin, R. Être et ordre.--Funke, G. Handeln aus Pflicht.--Kohlenberger, H. Zum Problem der Teleologie des Handelns.--Schaller, K. Theorie der Bildsamkeit.--Berlinger, R. Die Weltgestaltung der Philosophie.--Fink, E. Phronesis und Theoria.--Krońska, I. Atome und Menschen.--Dembowski, H. Martin Luthers Disputatio de Homine von 1536.--Heintel, E. Aristotelismus und Transzentalismus im "Begriff" bei Hegel.--Orth, E. W. Husserl und Hegel.--Baczko, B. Zum Problem der Leiblichkeit in der Anthropologie von Marx.--Kolakowski, L. (...) Richard Avenarius et le suicide apparent de la philosophie.--Biemel, W. Der Beginn von Prousts À la recherche du temps perdu.--Van Breda, H. L. L'itinéraire husserlien de la phénoménologie pure à la phénoménologie transcendentale. (shrink)

Many researchers studying subjective wellbeing (SWB) understand SWB as a concept that is close to Bentham’s notion of happiness. This conception of happiness is philosophically controversial, because it treats pleasure as a homogenous experience. I analyze an important deviation from Bentham in John Stuart Mill’s Utilitarianism and its relevance for SWB research: qualitative differences in pleasurable experiences. I argue that in cases where lives involving qualitatively different experiences are compared, Mill’s qualitative perspective is incompatible with an important assumption in the (...) SWB literature: that happiness can be meaningfully rated by people on a scale. I illustrate the problem by means of the question of whether becoming a parent makes people happier. I analyze whether the problem can be avoided on alternative views of happiness, but argue that on all plausible accounts of happiness, the problem persists. I conclude that the problem it poses for self-reported happiness is genuine and should be acknowledged by SWB researchers. I end by discussing the ways in which this conclusion can help the study of happiness move forward. (shrink)

Dit artikel tracht de grondslagen te leggen voor een aannemelijke theorie van organisatie. Het zet uiteen, dat het vermogen van iedere bevolkingsgroep, de hulpmiddelen effectief aan te wenden, in de eerste plaats afhankelijk is van de voorschriften en regelingen, die zij aanneemt voor de contrôle van haar natuurlijke hulpbronnen en productiemiddelen en de distributie van inkomen. Deze regels en voorschriften vormen tezamen hetgeen een georganiseerd proces wordt genoemd. De voornaamste stelling van het artikel is deze, dat een organisatie een groeiend (...) model is van relaties tusschen volken en de materialen in hun omgeving. Er zijn bepaalde relatie-beginselen, die een organisatie tot een levend geheel, haar endogenetisch, maken, d.w.z. haar uit zichzelf de energie doen voortbrengen om haar eigen levensprocessen te onderhouden. Een schending van deze principes -- zoo zet de schrijver uiteen -- veroorzaakt een vermindering van de levensvatbaarheid der organisatie, zoodat de energie, die noodig is om haar geraamte bijeen te houden van buiten-af moet worden aangevuld, d.w.z. uitwendig moet zijn ten opzichte van haar eigen activiteiten. Het schema van zulk een organisatie wordt exogenetisch genoemd. Een aantal voorbeelden wordt gegeven, om deze stelling te ondersteunen en de principes worden met een aantal gevallen geïllustreerd. De stelling toont aan, dat het sociale organisme de tendentie heeft exogenetisch te worden, wanneer het er niet in slaagt, de eischen van den mensch behoorlijk met die van zijn technologie in overeenstemming te brengen. De basis van deze verhouding, zoo toont de schrijver aan, ligt in drie integratiepunten, namelijk: 1. Het punt, waarin de relaties van individuen en groepen tot de natuurlijke hulpbronnen zijn bepaald. 2. Het punt, waarin de relaties van individuen en groepen tot de productiemiddelen zijn bepaald. 3. Het punt, waarin de betrekkelijke rechten van kapitaal en arbeid ten opzichte van de geproduceerde goederen zijn bepaald. Het artikel eindigt met een voorgesteld schema van organisatie van de sociale en economische krachten, die samenkomen in deze punten. (shrink)

It is common to posit a clear opposition between the values served by property systems and the value of the environment. To give the environment its due, this view holds, the role of private property needs to be limited. Support for this has been said to be found in Locke’s famous ‘enough and as good’ proviso. This article shows that this opposition is mistaken, and corrects the implied reading of Locke’s proviso. In reality, there is no opposition between property and (...) the environment. This is shown using Locke’s theory of appropriation, as well as the real-life case of instream water appropriation. (shrink)

An unresolved issue in the occupational health literature that is of both theoretical and practical importance is whether interpersonal conflicts, aggression and bullying at work are distinct or overlapping phenomena for exposed workers. In this study, we addressed this question empirically by employing a Latent Class (LC) analysis using cross-industry data from 6,175 Belgian workers. We found that a two-factor solution with a conflict-aggression factor and a bullying factor had the best fit. Employees with low exposure to workplace conflicts-aggression and (...) bullying perceived the phenomena as mostly overlapping. Reversely, employees who were exposed more frequently to the phenomena perceived them as more distinct - especially so for workplace bullying. Conflicts-aggression and bullying seem to be perceived as separate phenomena given their distinctive relationships with criterion variables in the domain of well-being and strain. These findings entail that a simple unifying approach or a single label for the three phenomena is not appropriate, at least from a measurement point of view and from the different perspectives of those exposed. Our results have important implications for the theoretical understanding of the concepts of interpersonal conflicts, aggression and bullying, and for practitioners who have to assist those involved with how to handle these problems and who have to develop legal as well as internal policies for the prevention and management of these issues at the workplace. (shrink)

Nursing Ethics has published several pleas for care ethics and/or relationality as the most promising ethical foundation for midwifery philosophy and practice. In this article, we stand by these calls, contributing to them with the identification of the structural form of violence that a care ethical relational approach to reproductive care is up against: that of “maternal separation”. Confronted with reproductive and obstetric violence globally, we show that a hegemonic racialized, instrumentalized, and individualized conception of pregnancy is responsible for a (...) severance of relationalities that are essential to safe reproductive care: (1) the relation between the person and their child or reproductive capabilities; and (2) the relation between the pregnant person and their community of care. We pinpoint a separation of the maternal relation in at least two discursive domains, namely, the juridical-political and the ethical-existential. Consequently, we plea for a radical re-imagination of maternal relationality, envisioning what care ethical midwifery, including abortion care, could be. (shrink)

Amsterdam University Press is a leading publisher of academic books, journals and textbooks in the Humanities and Social Sciences. Our aim is to make current research available to scholars, students, innovators, and the general public. AUP stands for scholarly excellence, global presence, and engagement with the international academic community.

ABSTRACT The traditional view holds that political philosophy should aim at the truth. By contrast, Avner de Shalit argues that political philosophers should do something different. According to him, they should work in direct consultation with “the people” in order to think through their theories about political institutions. This article defends the traditional aim of truth-seeking and shows the mistakes in De Shalit’s alternative approach.

This work details the theological sources and moral significance of the life and work of the Scottish moral philosopher Adam Smith (1723-1790). The panel of contributors deepen our understanding of Adam Smith in his religious and theological context and the significance of this understanding for contemporary moral, economic, and political challenges to modern social life. The chapters cover a broad range of disciplinary and historical concerns, from Smith's view of providence and his famous "invisible hand" to the role of self-interest (...) and benevolence in Smith's social and economic thought. A better appreciation for the moral and theological dimensions of Smith's thought provides not only a better understanding of Smith's own context and significance in the Scottish Enlightenment, but also promises to assist in meeting the perennial challenges of properly connecting economic realities to moral responsibility. The book is of interest to advanced students and scholars of the history of economic thought, historical and moral theology, intellectual history, political science and philosophy. (shrink)

In der Reihe werden herausragende monographische Untersuchungen und Sammelbände zu allen Aspekten der Philosophie Kants veröffentlicht, ebenso zum systematischen Verhältnis seiner Philosophie zu anderen philosophischen Ansätzen in Geschichte und Gegenwart. Veröffentlicht werden Studien, die einen innovativen Charakter haben und ausdrückliche Desiderate der Forschung erfüllen. Die Publikationen repräsentieren damit den aktuellsten Stand der Forschung.

In this short introduction, the guest editors present the main themes of the special issue.

Spatial relations are central to geometrical thinking. With respect to the classical elementary geometry of Euclid’s Elements, a distinction between co-exact, or qualitative, and exact, or metric, spatial relations has recently been advanced as fundamental. We tested the universality of intuitions of these relations in a group of Senegalese and Dutch participants. Participants performed an odd-one-out task with stimuli that in all but one case display a particular spatial relation between geometric objects. As the exact/co-exact distinction is closely related to (...) Kosslyn’s categorical/coordinate distinction, a set of stimuli for testing all four types was used. Results suggest that intuitions of all spatial relations tested are universal. Yet, culture has an important effect on performance: Dutch participants outperformed Senegalese participants and stimulus layouts affect the categorical and coordinate processing in different ways for the two groups. Differences in level of education within the Senegalese participants did not affect performance. (shrink)

In this article we provide an intrinsic characterization of the famous Howard–Bachmann ordinal in terms of a natural well-partial-ordering by showing that this ordinal can be realized as a maximal order type of a class of generalized trees with respect to a homeomorphic embeddability relation. We use our calculations to draw some conclusions about some corresponding subsystems of second order arithmetic. All these subsystems deal with versions of light-face Π11\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varPi ^1_1$$\end{document}-comprehension.

This article adopts the framework set out in ‘Associative Political Obligations’ to ask two further questions about the theory of associative political obligation. (i) Which of the different interpretations of the theory of associative political obligation is most plausible? And (ii) what would be the implications of such a view? It is argued that (i) the most attractive version of the argument is one according to which such obligations obtain only in morally acceptable communities, and only between what may be (...) called ‘thick’ members. And (ii) that such a theory should give up on at least some of the conclusions that associativist theorists have tried to defend, such as that associative political obligations can establish the legitimacy of states. However, it is also suggested that this should not be considered a regrettable retreat. (shrink)

We investigated how the perception of being dissimilar to others at work relates to employees’ felt inclusion, distinguishing between surface-level and deep-level dissimilarity. In addition, we tested the indirect relationships between surface-level and deep-level dissimilarity and work-related outcomes, through social inclusion. Furthermore, we tested the moderating role of a climate for inclusion in the relationship between perceived dissimilarity and felt inclusion. We analyzed survey data from 887 employees of a public service organization. An ANOVA showed that felt inclusion was lower (...) for individuals who perceived themselves as deep-level dissimilar compared to individuals who perceived themselves as similar, while felt inclusion did not differ among individuals who perceived themselves as surface-level similar or dissimilar. Furthermore, a moderated mediation analysis showed a negative conditional indirect relationship between deep-level dissimilarity and work-related outcomes through felt inclusion. Interestingly, while the moderation showed that a positive climate for inclusion buffered the negative relationship between deep-level dissimilarity and felt inclusion, it also positively related to feelings of inclusion among all employees, regardless of their perceived (dis)similarity. This research significantly improves our understanding of how perceived dissimilarity affects employees by distinguishing between surface-level and deep-level dissimilarity and by demonstrating the importance of a climate for inclusion. (shrink)

The overall trend toward globalization in design, greatly enhanced by digital technologies, has raised issues and challenges on how to preserve the cultural differences and values of different societies. There is a tendency to lose touch with local cultural values when designing artefacts for global use, and social nuances and traditions risk to be flattened or stereotyped in the pursuit of developing new technologies and products for the global society. Attempts to reduce the tension between the global and the local (...) in design can be seen in the development of standards and guidelines for cross-cultural design, that are mostly focused on user interface design. However, when moving from preferences, metaphors, appearance, and navigation toward cultural models of interaction and physical design, new methodologies and tools for cross-cultural design are needed. This paper describes a poetry-inspired design method for cross-cultural sharing within the design process. The approach uses poetry to sensitize the designer to the subtleties and diversity of a culture so that the design can be given new aesthetic and cultural significance. The methodology is exemplified by actual design cases developed within the course “Cultural Sensitivity” of the Master’s Degree Program in Industrial Design at Eindhoven University of Technology, where poetry was used for uncovering underlying or implicit assumptions, intercultural differences and similarities, as well as for general sensitization of young designers. (shrink)

Opposed to Norman's proposal, processing of affordance is likely to occur not solely in the dorsal stream but also in the ventral stream. Moreover, the dorsal stream might do more than just serve an important role in motor actions. It supports egocentric location coding as well. As such, it would possess a form of representational memory, contrary to Norman's proposal.

Although higher-level constructs often fail to explain the mechanisms underlying motivation, we argue that purely mechanistic approaches have limitations. Lower-level neural data help us identify “biologically plausible” mechanisms, while higher-level constructs are critical to formulate measurable behavioral outcomes when constructing computational models. Therefore, we propose that a multi-level, multi-measure approach is required to fully unpack the black box of motivated behavior.