Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Die traditionsreiche Reihe QUELLEN UND FORSCHUNGEN ZUR LITERATUR- UND KULTURGESCHICHTE gehört zum festen Bestand renommierter Publikationsforen der Deutschen Literaturwissenschaft. Von Mark-Georg Dehrmann und Christiane Witthöft herausgegeben, präsentiert die Reihe hochwertige wissenschaftliche Arbeiten, die literarische Texte im Zusammenhang mit kulturhistorischen Phänomenen untersuchen.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Accompanied by an introductory monograph and a full critical apparatus, this English-language edition of Karel van Mander’s _Grondt der edel, vry schilderconst_ (Foundation of the Noble, Free Art of Painting) provides unprecedented access to this crucially important art treatise on _schilderconst_ (the art of painting / picturing).

Patočka, J. Erinnerungen an Husserl.--Landgrebe, L. Philosophische Anthropologie - eine empirische Wissenschaft?--Schmidt, G. Was ist der Mensch?--Polin, R. Être et ordre.--Funke, G. Handeln aus Pflicht.--Kohlenberger, H. Zum Problem der Teleologie des Handelns.--Schaller, K. Theorie der Bildsamkeit.--Berlinger, R. Die Weltgestaltung der Philosophie.--Fink, E. Phronesis und Theoria.--Krońska, I. Atome und Menschen.--Dembowski, H. Martin Luthers Disputatio de Homine von 1536.--Heintel, E. Aristotelismus und Transzentalismus im "Begriff" bei Hegel.--Orth, E. W. Husserl und Hegel.--Baczko, B. Zum Problem der Leiblichkeit in der Anthropologie von Marx.--Kolakowski, L. (...) Richard Avenarius et le suicide apparent de la philosophie.--Biemel, W. Der Beginn von Prousts À la recherche du temps perdu.--Van Breda, H. L. L'itinéraire husserlien de la phénoménologie pure à la phénoménologie transcendentale. (shrink)

Dit artikel tracht de grondslagen te leggen voor een aannemelijke theorie van organisatie. Het zet uiteen, dat het vermogen van iedere bevolkingsgroep, de hulpmiddelen effectief aan te wenden, in de eerste plaats afhankelijk is van de voorschriften en regelingen, die zij aanneemt voor de contrôle van haar natuurlijke hulpbronnen en productiemiddelen en de distributie van inkomen. Deze regels en voorschriften vormen tezamen hetgeen een georganiseerd proces wordt genoemd. De voornaamste stelling van het artikel is deze, dat een organisatie een groeiend (...) model is van relaties tusschen volken en de materialen in hun omgeving. Er zijn bepaalde relatie-beginselen, die een organisatie tot een levend geheel, haar endogenetisch, maken, d.w.z. haar uit zichzelf de energie doen voortbrengen om haar eigen levensprocessen te onderhouden. Een schending van deze principes -- zoo zet de schrijver uiteen -- veroorzaakt een vermindering van de levensvatbaarheid der organisatie, zoodat de energie, die noodig is om haar geraamte bijeen te houden van buiten-af moet worden aangevuld, d.w.z. uitwendig moet zijn ten opzichte van haar eigen activiteiten. Het schema van zulk een organisatie wordt exogenetisch genoemd. Een aantal voorbeelden wordt gegeven, om deze stelling te ondersteunen en de principes worden met een aantal gevallen geïllustreerd. De stelling toont aan, dat het sociale organisme de tendentie heeft exogenetisch te worden, wanneer het er niet in slaagt, de eischen van den mensch behoorlijk met die van zijn technologie in overeenstemming te brengen. De basis van deze verhouding, zoo toont de schrijver aan, ligt in drie integratiepunten, namelijk: 1. Het punt, waarin de relaties van individuen en groepen tot de natuurlijke hulpbronnen zijn bepaald. 2. Het punt, waarin de relaties van individuen en groepen tot de productiemiddelen zijn bepaald. 3. Het punt, waarin de betrekkelijke rechten van kapitaal en arbeid ten opzichte van de geproduceerde goederen zijn bepaald. Het artikel eindigt met een voorgesteld schema van organisatie van de sociale en economische krachten, die samenkomen in deze punten. (shrink)

Many researchers studying subjective wellbeing (SWB) understand SWB as a concept that is close to Bentham’s notion of happiness. This conception of happiness is philosophically controversial, because it treats pleasure as a homogenous experience. I analyze an important deviation from Bentham in John Stuart Mill’s Utilitarianism and its relevance for SWB research: qualitative differences in pleasurable experiences. I argue that in cases where lives involving qualitatively different experiences are compared, Mill’s qualitative perspective is incompatible with an important assumption in the (...) SWB literature: that happiness can be meaningfully rated by people on a scale. I illustrate the problem by means of the question of whether becoming a parent makes people happier. I analyze whether the problem can be avoided on alternative views of happiness, but argue that on all plausible accounts of happiness, the problem persists. I conclude that the problem it poses for self-reported happiness is genuine and should be acknowledged by SWB researchers. I end by discussing the ways in which this conclusion can help the study of happiness move forward. (shrink)

An unresolved issue in the occupational health literature that is of both theoretical and practical importance is whether interpersonal conflicts, aggression and bullying at work are distinct or overlapping phenomena for exposed workers. In this study, we addressed this question empirically by employing a Latent Class (LC) analysis using cross-industry data from 6,175 Belgian workers. We found that a two-factor solution with a conflict-aggression factor and a bullying factor had the best fit. Employees with low exposure to workplace conflicts-aggression and (...) bullying perceived the phenomena as mostly overlapping. Reversely, employees who were exposed more frequently to the phenomena perceived them as more distinct - especially so for workplace bullying. Conflicts-aggression and bullying seem to be perceived as separate phenomena given their distinctive relationships with criterion variables in the domain of well-being and strain. These findings entail that a simple unifying approach or a single label for the three phenomena is not appropriate, at least from a measurement point of view and from the different perspectives of those exposed. Our results have important implications for the theoretical understanding of the concepts of interpersonal conflicts, aggression and bullying, and for practitioners who have to assist those involved with how to handle these problems and who have to develop legal as well as internal policies for the prevention and management of these issues at the workplace. (shrink)

This work details the theological sources and moral significance of the life and work of the Scottish moral philosopher Adam Smith (1723-1790). The panel of contributors deepen our understanding of Adam Smith in his religious and theological context and the significance of this understanding for contemporary moral, economic, and political challenges to modern social life. The chapters cover a broad range of disciplinary and historical concerns, from Smith's view of providence and his famous "invisible hand" to the role of self-interest (...) and benevolence in Smith's social and economic thought. A better appreciation for the moral and theological dimensions of Smith's thought provides not only a better understanding of Smith's own context and significance in the Scottish Enlightenment, but also promises to assist in meeting the perennial challenges of properly connecting economic realities to moral responsibility. The book is of interest to advanced students and scholars of the history of economic thought, historical and moral theology, intellectual history, political science and philosophy. (shrink)

In der Reihe werden herausragende monographische Untersuchungen und Sammelbände zu allen Aspekten der Philosophie Kants veröffentlicht, ebenso zum systematischen Verhältnis seiner Philosophie zu anderen philosophischen Ansätzen in Geschichte und Gegenwart. Veröffentlicht werden Studien, die einen innovativen Charakter haben und ausdrückliche Desiderate der Forschung erfüllen. Die Publikationen repräsentieren damit den aktuellsten Stand der Forschung.

In this short introduction, the guest editors present the main themes of the special issue.

The overall trend toward globalization in design, greatly enhanced by digital technologies, has raised issues and challenges on how to preserve the cultural differences and values of different societies. There is a tendency to lose touch with local cultural values when designing artefacts for global use, and social nuances and traditions risk to be flattened or stereotyped in the pursuit of developing new technologies and products for the global society. Attempts to reduce the tension between the global and the local (...) in design can be seen in the development of standards and guidelines for cross-cultural design, that are mostly focused on user interface design. However, when moving from preferences, metaphors, appearance, and navigation toward cultural models of interaction and physical design, new methodologies and tools for cross-cultural design are needed. This paper describes a poetry-inspired design method for cross-cultural sharing within the design process. The approach uses poetry to sensitize the designer to the subtleties and diversity of a culture so that the design can be given new aesthetic and cultural significance. The methodology is exemplified by actual design cases developed within the course “Cultural Sensitivity” of the Master’s Degree Program in Industrial Design at Eindhoven University of Technology, where poetry was used for uncovering underlying or implicit assumptions, intercultural differences and similarities, as well as for general sensitization of young designers. (shrink)

Opposed to Norman's proposal, processing of affordance is likely to occur not solely in the dorsal stream but also in the ventral stream. Moreover, the dorsal stream might do more than just serve an important role in motor actions. It supports egocentric location coding as well. As such, it would possess a form of representational memory, contrary to Norman's proposal.

In this article we provide an intrinsic characterization of the famous Howard–Bachmann ordinal in terms of a natural well-partial-ordering by showing that this ordinal can be realized as a maximal order type of a class of generalized trees with respect to a homeomorphic embeddability relation. We use our calculations to draw some conclusions about some corresponding subsystems of second order arithmetic. All these subsystems deal with versions of light-face Π11\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\varPi ^1_1$$\end{document}-comprehension.

Although higher-level constructs often fail to explain the mechanisms underlying motivation, we argue that purely mechanistic approaches have limitations. Lower-level neural data help us identify “biologically plausible” mechanisms, while higher-level constructs are critical to formulate measurable behavioral outcomes when constructing computational models. Therefore, we propose that a multi-level, multi-measure approach is required to fully unpack the black box of motivated behavior.

This article adopts the framework set out in ‘Associative Political Obligations’ to ask two further questions about the theory of associative political obligation. (i) Which of the different interpretations of the theory of associative political obligation is most plausible? And (ii) what would be the implications of such a view? It is argued that (i) the most attractive version of the argument is one according to which such obligations obtain only in morally acceptable communities, and only between what may be (...) called ‘thick’ members. And (ii) that such a theory should give up on at least some of the conclusions that associativist theorists have tried to defend, such as that associative political obligations can establish the legitimacy of states. However, it is also suggested that this should not be considered a regrettable retreat. (shrink)

The aim of the article is to report on research findings that could contribute to the development of decolonised academic material. Africanisation of curricula implies that education and training as well as praxis be informed by the reality of the South African context, the viewpoints of the people of South Africa and their descriptions of what is needed to build a just society. This is relevant to a variety of service professions. This article was presented from a trans-disciplinary framework, and (...) the term ‘professional carers’, including the social service and theology professions, was used. The discussion explored how academia can approach the development of curricula that will inform praxis and which is relevant to the African context. The terms ‘Africanisation’, ‘decolonisation’ and ‘contextualisation’ were linked, whereafter a developmental approach to the development of the content and presentation of academic material was proposed. The article is concluded with recommended strategic options for the development of Africanised curricula. (shrink)

Academics are, or ought to be, engaged in an impartial search for the truth. Many academics also are, but ought not to be, engaged in political activism. I defend a moral duty for academics to refrain from such activism. Ben Jones’ article in this journal rejects such a duty. This article responds to his objections, thereby more carefully formulating when and why political activism is morally problematic, and what burdens it may imply.